商品描述

Safety Description:S22;S24/25

1, physiology function:

28 alkanes are generally accepted anti-s in world tired material.BE withdrawn for the raw material by the purely natural plant rice chaff wax,

BE expressed its main function as a result by Si university T.K.Cureton Doctor in American Illinois research:

Name	1-Octacosanol
Synonyms	Cluytyl alcohol; Montanyl alcohol; Octacosyl alcohol; Policosanol
Chinese Names
Molecular Structure
Molecular Formula	C28H58O
Molecular Weight	410.76
CAS Registry Number	557-61-9
EINECS	209-181-2
Properties
Melting point	81-83°C
Boiling point	200-250°C
Water solubility	<0.1 g/100 mL at 21.5°C
Safety Data
Safety Description	S22;S24/25

(1)Promote to bear power, energy, physical strength;

(2)Raise to respond intelligent;

(3)Raising should arouse an ability;

(4)Promote the sex hormone function, ease muscle ache;

(5)Improve myocardial function;

(6)Reduce cholesterol, the blood fat, reduce constringency period blood pressure;

(7)Raising the machine body metabolizes.

2, quantity index sign:

Appearance:White powder

Molecular weight:410.5

Numerator structure type:

Molecular formula:CH3(CH2)27OH

Fuse sex:The water doesn't dissolve, 70-80 ° Cs dissolve in the fat clan and the sweet smell clan compound

The Rong orders:80-83 ° Cs

Name: 1-Octacosanol

Synoms:Octacosanol, Octacosyl alcohol Chemical

Name: 1-Octacosanol,n-Octacosanol

Common Name:montanyl alcohol,koranyl alcohol,policosanol

Molecular Formula: C28H58O

CAS Number: 557-61-9

MDL Number: MFCD00044770

Storage Temp: 2-8°C M.W: 410.77

Melting point:83.2~83.6℃

Boiling point:200~250℃/1mmHg(sublimation)

Proportion:0.7830g/ml(85℃)

State:White powder in wax state,no smell.

Colour and Odour: Granular or plate, white to off-white powder.

Odourless Stability: do not absorb moisture,stable for light and heat,stable in acid and b asification good character of bio-degradation.

Solubility:not soluble in water,soluble in n－Butyl alcohol,lsopropylalcohol,Eth yl ether,Chloroform, N-BUTYL ACETATE,alcohol, Petroleum Ether,ETC.

Heavy Metals: Pb NMT10mg/kg;

As NMT1.5mg/kg

Total Plate Count <1000CFU/gm

Yeast & mold <100CFU/gm E.coli Negative Salmonella Negative Staphylococcus Negative Aflatoxins ： <0.2ppb Absent

Loss on Drying: NMT0.5% Ash: NMT0.1%

[Series of MDidea Rice bran wax P.E. 1-Octacosanol ] Spec. available on sale: Rice bran wax P.E. Content (1-Octacosanol):1-Octacosanol 60%GC Rice bran wax P.E. 1-Octacosanol 90%GC Content (1-Octacosanol):1-Octacosanol 90%GC

QTY: on stock Terms: most competitive Quality: the best.

Functions and Mechanism

The research of Dr. Cureton from the University of Illinois, U.S.A., has reporte d on the usefulness of natural rice bran waxes. Additional research has been cond ucted in Cuba and elsewhere, establishing the usefulness of 1-Octacosanol (Polico sanol) in human diet. The key discoveries relating to the beneficial effects of i ngesting natural vegetable wax(especially rice bran wax) and the waxy alcohols co ntained within the wax are as follows:

Helps to lower cholesterol level in blood - Helps to improve sexual activity and performance - Helps to inhibit lipid peroxidation - Help to improve endurance, increase vitality, and promote physical strength - Improve and sharpen muscle reflexes - Improve the human body’s resistance to stress - Stimulate the production of sex hormones and prevent muscle spasms - Improve the function of the heart muscle (myocardium) - Lessen vascular constriction and help lower blood pressure - Help to elevate the basal metabolism - Help to increase the hypotensivef effect of beta-blockers - Help to protect endothelial cells

Applications and Usage Levels

Natural Octacosanol powder can be used to prepare various kinds of dietary suppl ements and healthy foods the support athletic and sexal. Usage: Typical usage levels range from 0.5～10 mg per serving.

Applications in Pharmacy

The usage of high pure Natural Octacosanol in pharmacy is now coming into a fast developing period. As this natural material can maintain and lower existing norm al cholesterol levels in the blood, it has great significance in studying and pro ducing the natural Octacosanol. Recently, Pharmanex is the first company in the U nited States to market policosanol (Octacosanol) from beeswax extract.

Applications in Beverage and Food

Natural Octacosanol can be used to formulate sports-type, electrolyte replacemen t, and carbohydrate-loading beverages. Various value-added, health-oriented bever ages can be prepared using Octacosanol. To make water-based beverages, MDidea Oct acosanol should first be dissolved in ethyl alcohol or emulsified with lecithin o r other high HLB (Hydrophobic Lipophilic Balance) emulsifier before being added t o beverage formulations. However, because Octacosanol is a lipid, it can be more easily blended into products that contain a high percentage of oils such as butte r, margarine, vegetable oils, and other high fat products. The addition of MDidea Octacosanol could be an excellent way for manufacturers to create "Healthy Fats" that can promote healthy cholesterol level,

Special Dietary Products

Natural Octacosanol can be used to prepare various types of dietary supplement t ablets or capsules for the endurance of athletes, the elderly and those who are c oncerned about their high blood cholesterol level. MDidea Octacosanol can be blen ded with special grades of defatted, natural, and fully stabilized, wheat germ po wders to take advantage of the nutritional synergy between these two related subs tances (wheat germ contains a rich supply of Octacosanol). Possibilities for cons umer products using MDidea Octacosanol may include sports endurance supplements, weight-loss products, energy-boosting products, stress reducing supplements, sexu al performance products, and cardiovascular support products.

Market Information

Although 1-octacosanol has been researched in Cuba, American and China for many years since the last century, the marketing of this product is only several years old. However, as a natural and new material, the fast development of deep proces sing products and rising of price, we can see a great potential for the market of Octacosanol.

According to market surverys, many beverages have octacosanol liquid as an addit ive. In Japan in a two months period, 2 million cases of a beverage with octacosa nol content has been sold. It is estimated that the sales volume will be over 10 Million cases for the octacosanol beverage in the Japanese market. In America, th ere are many series of octacosanol healthcare foods and octacosanol and Vitamin’ s compounds formulas in the market, and these products have been well received in American healthcare foods market. In Australia, Korea and Eastern-South countrie s, there are various types of natural octacosanol dietary supplements and beverag es.

In a short, in international markets, the demand for octacosanol as the material for medicine and healthcare food is exceeding supply.

Applications and Usage Levels

Natural Octacosanol powder can be used to prepare various kinds of dietary suppl ements and healthy foods the support athletic and sexal. Usage: Typical usage levels range from 0.5～10 mg per serving.

Applications in Pharmacy

The usage of high pure Natural Octacosanol in pharmacy is now coming into a fast developing period. As this natural material can maintain and lower existing norm al cholesterol levels in the blood, it has great significance in studying and pro ducing the natural Octacosanol. Recently, Pharmanex is the first company in the U nited States to market policosanol (Octacosanol) from beeswax extract.

Applications in Beverage and Food

Natural Octacosanol can be used to formulate sports-type, electrolyte replacemen t, and carbohydrate-loading beverages. Various value-added, health-oriented bever ages can be prepared using Octacosanol. To make water-based beverages, MDidea Octacosanol should first be dissolved in e thyl alcohol or emulsified with lecithin or other high HLB (Hydrophobic Lipophili c Balance) emulsifier before being added to beverage formulations. However, becau se Octacosanol is a lipid, it can be more easily blended into products that conta in a high percentage of oils such as butter, margarine, vegetable oils, and other high fat products. The addition of MDidea Octacosanol could be an excellent way for manufacturers to create "Healthy Fats" that can promote healthy cholesterol l evel,

Special Dietary Products Natural Octacosanol can be used to prepare various types of dietary supplement t ablets or capsules for the endurance of athletes, the elderly and those who are c oncerned about their high blood cholesterol level. MDidea Octacosanol can be blen ded with special grades of defatted, natural, and fully stabilized, wheat germ po wders to take advantage of the nutritional synergy between these two related subs tances (wheat germ contains a rich supply of Octacosanol). Possibilities for cons umer products using MDidea Octacosanol may include sports endurance supplements, weight-loss products, energy-boosting products, stress reducing supplements, sexu al performance products, and cardiovascular support products.

In Details and more reference.

Octacosanol has been used in connection with the following conditions (refer to the individual health concern for complete information):

What does it do? Studies indicate that octacosanol allows for the efficient conversion of food an d storage fuels into biological energy, resulting in increased muscle strength, e ndurance, vigor, quicker reaction and faster recovery times. These preliminary studies found that octacosanol had promising effects on endura nce, reaction time, and other measures of exercise capacity.

Rating Health Concerns

Athletic performance ,Athletic support,Sport's performance,Performance Enhanceme nt. Octacosanol has been clinically proven to increase oxygen utilization during exe rcise or workouts. It also improves glycogen storage in your body's muscles. The results of octacosanol supplementation are it increases stamina, increases e ndurance, reduces high altitude stress, improves your reaction time, and helps ge t oxygen to your body tissue. Some people also use octacosanol to increase muscle size or mass.

A dietary supplement to support endurance and proper nerve function.

Octacosanol supports proper muscle glycogen storage, endurance, muscle strength, nerve function, oxygen utilization, and recovery time after strenuous exercise. Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit. Endurance Octacosanol can also benefit those people who get muscle pain after workout or o ther exercise. It can help with other neuromuscular disorders as well.

Energy High Cholesterol.

Octacosanol also has the additional benefit that it helps lower blood cholestero l levels. Octacosanol lowers LDL cholesterol while raising HDL cholesterol. It appears to inhibit the body’s production of cholesterol. Octacosanol+™ contains the fall range of Poli cosanols that have been foun d beneficial in bringing Cholesterol into a more healthy normal range and reducin g elevated tryglycenide levels. Policosanol is indicated as an adjunct to dietary and lifestyle recommendations to reduce elevated LDL-C and total cholesterol levels. Its primarily application is in type II hypercholesterolemia including IIa subtype (characterized by elevat ed total serum cholesterol and LDL-C levels) and IIb subtype (mixed hypercholeste rolemia characterized by elevated total serum cholesterol, LDL-C and triglyceride levels). Policosanol can also be used as an alternative to aspirin as an anti-platelet ag ent.

Parkinson's disease

Octacosanol also appears to help treat atherosclerosis when it affects neck arte ries.

Ability to reduce cholesterol: These findings show the effectiveness of low dose of policosanol lowering total cholesterol and LDL levels and suggest a CHD [coronary heart disease] improvement in middle-aged patients with primary or marginal hyperlipidemia.

Ability to reduce platelet aggregation: The present results demonstrate that policosanol (20 mg day-1) is as effective a s ASA [(aspirin), in reducing platelet aggregation] (100 mg day-1). Moreover, com bination therapy shows some advantages compared with the respective monotherapies .

Tolerabilty: No patient withdrew from the study because of adverse effects. No drug-related c linical or biochemical adverse side-effects were observed. Any adverse experience s reported were mild and transient; moreover, no significant differences were obt ained when compared with those reported by the placebo group. The results indicat e that policosanol administered for two years to patients with type II hyperchole sterolaemia shows a maintained efficacy as well as very good safety and tolerabil ity.

Therapeutic Uses Reasonably good evidence tells us that policosanol can significantly improve cho lesterol levels, to approximately the same extent as drugs in the statin family. Policosanol also appears to be helpful for intermittent claudication. The only evidence for octacosanol as a performance enhancer comes from one small double-blind trial with marginal results. Marginal benefits were also seen in a very small double-blind trial of individua ls with Parkinson's. However, octacosanol might interfere with the drug levodopa, used for Parkinson's disease. In a small double-blind trial, octacosanol failed to produce any benefits in amy otrophic lateral sclerosis.26 Other Applications and Functions Dietetic and Pharmaceutical Applications Natural octacosanol can be used to prepare various kinds of health food suppleme nts, healthy beverages, and pharmaceuticals. Octacosanol is an useful supplement for exercisers and indispensable nutrient fo r professional athletes. It decrease blood pressure and pulse frecuence during an d after exercise. Improve muscle glycogen storage. Improvement of stamina and endurance of exercisers. Improvement of reaction time. Stability of basal metabolic rate under stress. Reduction of blood cholesterol levels. Cosmetic Industry In antiwrinkle products. In hair growth promoters. In nails care products.

In brief,Octacosanol has many useful functions as following:

(1) Help to lower cholesterol levels in the blood;

(2) Help inhibit lipid peroxidation.

(3) Help improve endurance, increase vitality,and promote physical strength,

(4) Improve and sharpen the muscle reflexes;Improve the human body resistance to stress;

(5) Improve the function of the heart muscle (myocardium);

(6) Lessen vascular constriction and help lower blood pressure,

(7) Stimulate the production of sex hormones and prevent muscle spasms;

(8) Help to elevate the basal metabolism;

(9) Help to increase the hypotensive effect of betablockers.

(10) Help to protect endothelial cells.

28 alkane Chuns are to just start is derived from a wheat acrospire.Although can also sample 28 alkane Chuns from the whole grain, want to acquire the whole grain that 1,00028 alkane Chuns of the milligrams want to consume 10 pounds.The research shows 28 alkane Chuns are the good materials that improves physical strength.Therefore, it to those exercise behind the muscle ache or bear the power shortage of the persons have a very great help.Was confirmed by clinic, ability while exercising increase the exploitation of the oxygen.28 alkane Chuns also reduce blood cholesterol, muscle to atrophied and the pathological changes of other nerve muscles.

Have already known 28 alkane Chuns can improve a muscle to save and bear power and respond time, ease high mountain phobia and help the organization oxygen in the Zhu of the liver carbohydrate today with(oxygenation).All have 28 alkane Chuns of the jot in a lot of vegetable oils, this is a kind of natural and born material.28 alkane Chuns is a kind of draw from the plant chemistry material of delicacy, can strengthen physical strength, promote the utilization of the oxygen, even can prevent a heart attack.28 alkane Chuns are also the best food source of the Wei his Es.(the vitamin E is another one the specific name row 100 kinds of member of the materials with aging popular anti-s)

28 good food source of the alkane Chuns include the wheat acrospire, whole corn, spinach and purple flower clover etc..Promoting the vitality(the Improve Stamina) research points out, 28 alkane Chuns can reduce the occurrence rate of the anoxia, that is to say, it can help body to make it at the pressure appearance make use of oxygen more efficiently.So, if you took 28 alkane Chuns, then relatively allowing of no easy spirit to pant Xu after doing the violent physique exercise through.

To the heart attack help(the Heart Disease)28 alkane Chuns have the plant stearine Chun, this kind of compound can reduce the animal body and the cholesterol content in the human body.Besides, 28 alkane Chuns the high quantity vitamin E contained can also by in keep the low density fat egg white("bad of" cholesterol) from oxidizing and reduce the cholesterol content in the body.(this kind of oxidizes to cause importance of the artery occurrence blood Ning piece jam phenomenon)

28 physiology function of the alkane Chuns

Are 28 alkane Chuns in the food work?Medium of applied food industry, mainly derive from of many item care function.28 alkane Chuns are the accelerants that declines the blood calcium vegetable formation, can be used for curing an excessive bone soft disease of the blood calcium;Cure high cholesterol with the high fat egg white blood type and the disease, prevent cardiovascular occurrence;Strengthen the animal and the mankind's sexual function.Cosmetics with 28 alkane Chuns, can promote the circulation of the blood and activate cell.

28 safety of the alkane Chuns

28 safety of the alkane Chuns are very high.Was taken orally by small white rat to experiment, 28 LD50 of the alkane Chuns are above for 18000 mgs/kgs, safety ratio table salt(the LD 50=3000 mgs/kg) lead high.

28 alkane Chuns of?Quantity

Is the usage quantity of 28 the alkane Chuns very small?, Appear health care result for the ability body.Everybody absorbs a 5-10 mgs everyday or so, eat 6-8s, can immediately acquire ideal result.

Octacosanol Side Effects
No side effects of any significance have yet been reported with octacosanol, but then again hardly any research has been done with this nutrient in terms of long term benefit or risk to human consumption.

Octacosanol Research Update
Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes.

Very long chain fatty alcohols obtained from plant waxes and beeswax have been reported to lower plasma cholesterol in humans. This review discusses nutritional or regulatory effects produced by wax esters or aliphatic acids and alcohols found in unrefined cereal grains, beeswax, and many plant-derived foods. Reports suggest that 5-20 mg per day of mixed C24-C34 alcohols, including octacosanol and triacontanol, lower low-density lipoprotein (LDL) cholesterol by 21%-29% and raise high-density lipoprotein cholesterol by 8%-15%. Wax esters are hydrolyzed by a bile salt-dependent pancreatic carboxyl esterase, releasing long chain alcohols and fatty acids that are absorbed in the gastrointestinal tract. Studies of fatty alcohol metabolism in fibroblasts suggest that very long chain fatty alcohols, fatty aldehydes, and fatty acids are reversibly inter-converted in a fatty alcohol cycle. The metabolism of these compounds is impaired in several inherited human peroxisomal disorders, including adrenoleukodystrophy and Sjogren-Larsson syndrome. Reports on dietary management of these diseases confirm that very long chain fatty acids (VLCFA) are normal constituents of the human diet and are synthesized endogenously. Concentrations of VLCFA in blood plasma increase during fasting and when children are placed on ketogenic diets to suppress seizures. Existing data support the hypothesis that VLCFA exert regulatory roles in cholesterol metabolism in the peroxisome and also alter LDL uptake and metabolism.

Octacosanol supplementation increases running endurance time and improves biochemical parameters after exhaustion in trained rats.

This study evaluated the effects of octacosanol on running performance and related biochemical parameters in exercise-trained rats run to exhaustion on a treadmill. Male Sprague-Dawley rats were randomly assigned to one of three groups - sedentary control group (SC), exercise-trained control group (EC), and exercise-trained, octacosanol-supplemented group (EO) - and raised on either control or octacosanol (0.75%)-supplemented diet with (or without for SC rats) exercise-training for 4 weeks. EC rats ran 184% longer until exhaustion than SC rats, while octacosanol-supplemented trained rats ran 46% longer than EC rats. Under the exhausted state immediately following the running performance test, EO rats exhibited significantly higher plasma ammonia and lactate concentrations compared with the values for EC rats. Although EO rats ran significantly longer until exhausted, their plasma glucose level and gastronecmius muscle glycogen concentration were not significantly different from those of EC rats. Dietary supplementation of octacosanol resulted in significantly higher creatine phosphokinase activity in plasma (44% increase) and citrate synthase activity in muscle (16% increase) of exercise-trained rats. These results suggest that the ergogenic properties of octacosanol include the sparing of muscle glycogen stores and increases in the oxidative capacity in the muscle of exercise-trained rats.

Effects of octacosanol in food physiological parameters in tail-suspended rats

The purposes of the experiment were to observe the physiological effects of octacosanol in food on tail-suspended rats and to investigate the possibility of using octacosanol in health food for astronauts. 24 male Wistar rats were randomly divided into free action control, tail-suspension and tail suspension plus octacosanol (TSO) groups. Octacosanol was emulsified into water by supersound and given to TSO rats with a dosage of 25 mg/kg wt d. The results showed that octacosanol elevated the weight of thymus, improved biomechanical properties of the femur and improved membrane fluidity of red blood cell. It suggests that octacosanol can counteract some effects of simulated weightlessness on rats. Therefore, octacosanol may be added to natural foods to benefit the health of cosmonauts.

Trial of octacosanol in amyotrophic lateral sclerosis.

Octacosanol was tried in amyotrophic lateral sclerosis in a double-blind, placebo-controlled, crossover design. Neurologic and pulmonary function evaluations showed no benefit.

Applied foreground

Can system become various healthy function food, can produce candy, pastry, beverage with the future life, using 28 Chun manufacturing process athlete beverages at Japan, appearing on market two months to sell 1,000,000 anticipate a year marketability 6,000,000 boxes mutually.At above in the province food institute of Mainland China Zhejiang the century starts in 8's, concentrate on the development of the deluxe Chun series product and produce, have already become mature of craft, because 28 alkane Chuns have special physiology function, applying to do the new generation exercise beverage and developing high ability the additive of the beverage, the market foreground is very vast.

The application that is in making up hairdressing

Can promote hemal circulation of skin with activate cell, have already eliminated inflammation, prevent and cure skin disease, as Beri-Beri, wet Zhen, pimple etc. effect.

Increasing the blood absorbs more oxygens, also because it has abundant natural anti- to oxidize, can let the skin look to get up more more smooth and younger, can help treatment the scar formation and gestation Wen and help the formation of the new cell, promote circulation and help the repair and maintenance sun to the skin causes of hurt.

Care a food, 28 alkane Chuns can be a main function factor, increasing in the anti- the tired food, in the anti- decrepitude food, bear the anoxia food and reduce cholesterol etc. food in, is an all very nice additive, is very good to the body.